Potassium Carbonate → HCID 59526200, compound

Participants

Reaction Conditions

Reaction Steps

2,6-Dibromopyridine (710 mg, 3.00 mmol), potassium carbonate (1184 mg, 8.57 mmol), PdCl2(dppf) (104 mg, 0.14 mmol) were placed in a flask and the flask was purged with argon. 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyran (600 mg, 2.86 mmol) was dissolved in degassed DMF (19 mL), added to the reaction mixture and 5 argon/vacuum purge cycles were performed. The reaction was heated at 80° C. overnight. The reaction was cooled to room temperature, diluted with ethyl acetate, washed with water, dried over magnesium sulfate, filtered, and concentrated. The crude mixture was purified by silica gel chromatography to yield the title compound.

Provenance & Evidence