2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59526110, compound

HRID 385814Notes

Reaction equation

HRID 385814 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]2[CH2:30][CH2:31][O:32][CH2:33][CH:34]=2)[N:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]3[CH2:30][CH2:31][O:32][CH2:33][CH:34]=3)[N:24]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526200HCID 59526200, compound

Product 1

HCID 59526110HCID 59526110, compound

Procedure

The title compound was prepared by using the procedure listed in Example 1 with 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.24 g, 0.75 mmol) and 2-bromo-6-(3,6-dihydro-2H-pyran-4-yl)pyridine (0.18 g, 0.74 mmol) as the starting materials.

Sources & evidence

ORD record
ord-6814769da3c64b8ab513a4ef04ce3777
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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