HCID 59525963, compound → HCID 59526008, compound

Participants

Reaction Steps

Benzyl (3S,4S)-4-[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]-3,4-dihydroxypiperidine-1-carboxylate (100 mg, 0.16 mmol) was dissolved in methanol (4.6 mL) and subjected to the H-cube hydrogenator machine, where the solution passed through a palladium on carbon cartridge at 0.5 mL/min at a temperature of 35° C. and a hydrogen pressure of 40 PSI. Once complete, the solution was concentrated and the crude residue was purified by reverse phase HPLC to yield the title compound.

Provenance & Evidence