2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59526054, compound

HRID 385823Notes

Reaction equation

HRID 385823 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].[CH2:22]([O:29][C:30](=[O:47])[N:31]([CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[C:42](Br)[N:41]=1)[CH2:32][C:33]([NH:35][CH:36]([CH3:38])[CH3:37])=[O:34])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:22]([O:29][C:30](=[O:47])[N:31]([CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[C:42]([NH:1][C:2]2[S:3][C:4]([C:10]3[C:11]([F:21])=[CH:12][C:13]([C:17]([OH:20])([CH3:18])[CH3:19])=[CH:14][C:15]=3[F:16])=[CH:5][C:6]=2[C:7]([NH2:9])=[O:8])[N:41]=1)[CH2:32][C:33]([NH:35][CH:36]([CH3:38])[CH3:37])=[O:34])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525932HCID 59525932, compound

Product 1

HCID 59526054HCID 59526054, compound

Procedure

The title compound was prepared by using the procedure described in Example 1 with 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.92 g, 0.30 mmol) and benzyl[(6-bromopyridin-2-yl)methyl][2-(isopropylamino)-2-oxoethyl]carbamate (0.12 g, 0.30 mmol) as the starting materials.

Sources & evidence

ORD record
ord-b154d92aa46f423d9839dfff1350b019
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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