HCID 59526054, compound → HCID 59525601, compound

Participants

Reaction Steps

Benzyl{[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}[2-(isopropylamino)-2-oxoethyl]carbamate (83 mg, 0.13 mmol) was dissolved in methanol. Palladium on carbon (0.68 mg, 6.4 μmol) was added and a hydrogen balloon was placed on top. The solution was evacuated and then charged with hydrogen several times. The reaction was stirred for 3 hours. The solution was filtered through celite and concentrated. The crude residue was purified by reverse phase HPLC (10-100% acetonitrile/water+0.05% TFA modifier) to yield the title compound.

Provenance & Evidence