Ethanolamine → HCID 59526349, compound

Participants

Reaction Steps

A mixture of N-[(benzyloxy)carbonyl]-N-[(6-bromopyridin-2-yl)methyl]glycine (Example 179, Step 3) (112 mg, 0.295 mmol), 2-aminoethanol (18 μL, 0.295 mmol), HOBt (59 mg, 0.325 mmol) and PS-CDI (586 mg, 0.732 mmol) in DCM (4.0 mL) was irradiated in the microwave at 100° C. for 5 min. To this mixture, MP-isocyanate (967 mg, 1.22 mmol), PS-trisamine (393 mg, 1.34 mmol) and DCM (5.0 mL) were added and irradiated in the microwave at 100° C. for 10 min. The reaction mixture was filtered, washed with DCM and the filtrate was concentrated in vacuo to afford the title compound as a clear oil.

Provenance & Evidence