2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525950, compound

HRID 385831Notes

Reaction equation

HRID 385831 reaction equation
Br[C:2]1[N:7]=[C:6]([CH2:8][N:9]([S:19]([CH3:22])(=[O:21])=[O:20])[CH2:10][C:11]([NH:13][CH:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[O:12])[CH:5]=[CH:4][CH:3]=1.[NH2:23][C:24]1[S:25][C:26]([C:32]2[C:37]([F:38])=[CH:36][C:35]([C:39]([OH:42])([CH3:41])[CH3:40])=[CH:34][C:33]=2[F:43])=[CH:27][C:28]=1[C:29]([NH2:31])=[O:30]>>[CH:14]1([NH:13][C:11](=[O:12])[CH2:10][N:9]([CH2:8][C:6]2[N:7]=[C:2]([NH:23][C:24]3[S:25][C:26]([C:32]4[C:33]([F:43])=[CH:34][C:35]([C:39]([OH:42])([CH3:40])[CH3:41])=[CH:36][C:37]=4[F:38])=[CH:27][C:28]=3[C:29]([NH2:31])=[O:30])[CH:3]=[CH:4][CH:5]=2)[S:19]([CH3:22])(=[O:21])=[O:20])[CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525667HCID 59525667, compound

Product 1

HCID 59525950HCID 59525950, compound

Procedure

The title compound was prepared as described in Example 1 using N2-[(6-bromopyridin-2-yl)methyl]-N-cyclopentyl-N2-(methylsulfonyl)glycinamide (0.15 g, 0.38 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.12 g, 0.38 mmol) as the starting materials.

Sources & evidence

ORD record
ord-2eac7fa8f3b543ebbfe0ebb0d95a865e
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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