2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59526004, compound

HRID 385833Notes

Reaction equation

HRID 385833 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[N:28]=[C:27]([CH2:29][N:30]([CH3:40])[CH2:31][C:32]([NH:34][CH:35]2[CH2:39][CH2:38][CH2:37][CH2:36]2)=[O:33])[CH:26]=[CH:25][CH:24]=1>>[CH:35]1([NH:34][C:32](=[O:33])[CH2:31][N:30]([CH2:29][C:27]2[N:28]=[C:23]([NH:1][C:2]3[S:3][C:4]([C:10]4[C:11]([F:21])=[CH:12][C:13]([C:17]([OH:20])([CH3:18])[CH3:19])=[CH:14][C:15]=4[F:16])=[CH:5][C:6]=3[C:7]([NH2:9])=[O:8])[CH:24]=[CH:25][CH:26]=2)[CH3:40])[CH2:39][CH2:38][CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525902HCID 59525902, compound

Product 1

HCID 59526004HCID 59526004, compound

Procedure

The title compound was prepared by using the procedure listed in Example 1 with 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.12 g, 0.38 mmol) and N2-[(6-bromopyridin-2-yl)methyl]-N-cyclopentyl-N2-methylglycinamide (0.11 g, 0.34 mmol) as the starting materials.

Sources & evidence

ORD record
ord-3b219bf1098c44108b27d6c9679b70a5
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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