2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59526089, compound

HRID 385835Notes

Reaction equation

HRID 385835 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].[C:22]([N:25]([CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[C:38](Br)[N:37]=1)[CH2:26][C:27]([NH:29][CH:30]1[CH2:34][CH2:33][CH2:32][CH2:31]1)=[O:28])(=[O:24])[CH3:23]>>[C:22]([N:25]([CH2:35][C:36]1[N:37]=[C:38]([NH:1][C:2]2[S:3][C:4]([C:10]3[C:11]([F:21])=[CH:12][C:13]([C:17]([OH:20])([CH3:18])[CH3:19])=[CH:14][C:15]=3[F:16])=[CH:5][C:6]=2[C:7]([NH2:9])=[O:8])[CH:39]=[CH:40][CH:41]=1)[CH2:26][C:27]([NH:29][CH:30]1[CH2:34][CH2:33][CH2:32][CH2:31]1)=[O:28])(=[O:24])[CH3:23]

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525821HCID 59525821, compound

Product 1

HCID 59526089HCID 59526089, compound

Procedure

The title compound was prepared using the procedure described in Example 1 with 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.12 g, 0.38 mmol) and N2-acetyl-N2-[(6-bromopyridin-2-yl)methyl]-N-cyclopentylglycinamide (0.14 g, 0.38 mmol) as the starting materials.

Sources & evidence

ORD record
ord-880b5a54e1c24a30bbf22d8424413cd2
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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