2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525750, compound

HRID 385837Notes

Reaction equation

HRID 385837 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:22]1[C:23]([CH2:28][N:29]2[CH2:33][CH2:32][CH2:31][C:30]2=[O:34])=[N:24][CH:25]=[CH:26][CH:27]=1>>[F:20][C:11]1[CH:12]=[C:13]([C:16]([OH:19])([CH3:17])[CH3:18])[CH:14]=[CH:15][C:10]=1[C:4]1[S:3][C:2]([NH:1][C:25]2[CH:26]=[CH:27][CH:22]=[C:23]([CH2:28][N:29]3[CH2:33][CH2:32][CH2:31][C:30]3=[O:34])[N:24]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 68670322HCID 68670322, compound

Product 1

HCID 59525750HCID 59525750, compound

Procedure

The title compound was prepared by using the procedure listed in Example 1 with 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.14 g, 0.48 mmol) and 1-[(bromopyridin-2-yl)methyl]pyrrolidin-2-one (0.12 g, 0.47 mmol) as starting materials.

Sources & evidence

ORD record
ord-c10ada1256194d27838e056496e8ba21
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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