Lithium Hydroxide → HCID 59526147, compound

Participants

Reaction Steps

To a solution of methyl[(6-bromopyridin-2-yl)methoxy]acetate (2.5 g, 19.2 mmol) in methanol (50 mL) was added aqueous lithium hydroxide (1M) dropwise over 15 min at 0° C. The reaction mixture was allowed to warm to room temperature overnight. The organic solvent was removed in vacuum and the residual aqueous solution was extracted with Et2O, and the aqueous phase was acidified to pH 2 with 1 N HCl. The aqueous phase was extracted with CH2Cl2 (3×100 mL). The combined organic extracts were dried and concentrated to afford the title compound.

Provenance & Evidence