Morpholine → HCID 59525697, compound

Participants

Reaction Steps

To a solution of [(6-bromopyridin-2-yl)methoxy]acetic acid (1.6 g, 7.5 mmol) and morpholine (0.65 g, 7.5 mmol) in dichloromethane at 0° C. was added N-ethyl-N-isopropylpropan-2-amine (3.9 mL, 22.5 mmol), 1-hydroxybenzotriazole hydrate (1.5 g, 11.25 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.1 g, 11.25 mmol). The reaction mixture was stirred at room temperature overnight. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography, eluting with ethyl acetate:hexanes (3:7) to afford the title compound.

Provenance & Evidence