2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525946, compound

HRID 385848Notes

Reaction equation

HRID 385848 reaction equation
[CH3:1][NH:2][C:3](=[O:13])[O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8](Br)[N:7]=1.[NH2:14][C:15]1[S:16][C:17]([C:23]2[C:28]([F:29])=[CH:27][C:26]([C:30]([OH:33])([CH3:32])[CH3:31])=[CH:25][C:24]=2[F:34])=[CH:18][C:19]=1[C:20]([NH2:22])=[O:21]>>[CH3:1][NH:2][C:3](=[O:13])[O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:14][C:15]2[S:16][C:17]([C:23]3[C:24]([F:34])=[CH:25][C:26]([C:30]([OH:33])([CH3:31])[CH3:32])=[CH:27][C:28]=3[F:29])=[CH:18][C:19]=2[C:20]([NH2:22])=[O:21])[N:7]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525695HCID 59525695, compound

Product 1

HCID 59525946HCID 59525946, compound

Procedure

The title compound was prepared according to the general procedure in Example 1 using (6-bromopyridin-2-yl)methyl methylcarbamate (149 mg, 0.61 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (200 mg, 0.64 mmol) as the starting materials.

Sources & evidence

ORD record
ord-d2f5f6cea63f4629ba5e835f155c8e8e
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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