2-(6-Bromopyridin-2-yl)ethanol → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 385857Notes

Reaction equation

HRID 385857 reaction equation
Br[C:2]1[N:7]=[C:6]([CH2:8][CH2:9][OH:10])[CH:5]=[CH:4][CH:3]=1.[NH2:11][C:12]1[S:13][C:14]([C:20]2[C:25]([F:26])=[CH:24][C:23]([C:27]([OH:30])([CH3:29])[CH3:28])=[CH:22][C:21]=2[F:31])=[CH:15][C:16]=1[C:17]([NH2:19])=[O:18]>>[F:31][C:21]1[CH:22]=[C:23]([C:27]([OH:30])([CH3:29])[CH3:28])[CH:24]=[C:25]([F:26])[C:20]=1[C:14]1[S:13][C:12]([NH:11][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][CH2:9][OH:10])[N:7]=2)=[C:16]([C:17]([NH2:19])=[O:18])[CH:15]=1

Participants

3

Reactant 2

HCID 468357132-(6-Bromopyridin-2-yl)ethanolHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595259405-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was prepared as described in Example 1 using 2-(6-bromopyridin-2-yl)ethanol (48 mg, 0.24 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (75 mg, 0.24 mmol) as the starting materials.

Sources & evidence

ORD record
ord-ebf53645db9d4c308a4bb259040d76b0
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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