2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-methoxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 385859Notes

Reaction equation

HRID 385859 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH2:9][O:10][CH3:11])[N:3]=1.[NH2:12][C:13]1[S:14][C:15]([C:21]2[C:26]([F:27])=[CH:25][C:24]([C:28]([OH:31])([CH3:30])[CH3:29])=[CH:23][C:22]=2[F:32])=[CH:16][C:17]=1[C:18]([NH2:20])=[O:19]>>[F:32][C:22]1[CH:23]=[C:24]([C:28]([OH:31])([CH3:30])[CH3:29])[CH:25]=[C:26]([F:27])[C:21]=1[C:15]1[S:14][C:13]([NH:12][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH2:9][O:10][CH3:11])[N:3]=2)=[C:17]([C:18]([NH2:20])=[O:19])[CH:16]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595262782-Bromo-6-(2-methoxyethyl)pyridine

Product 1

HCID 595262635-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-methoxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Example 1 using 2-bromo-6-(2-methoxyethyl)pyridine (42 mg, 0.19 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (60 mg, 0.19 mmol) as the starting materials.

Sources & evidence

ORD record
ord-d9ccc9775c644fe2bece8de8e2fef57f
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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