反应详情

In analogy to Example 89, the title compound was prepared from N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6,7-dihydro-5H-pyrrolo[3′,4′:4,5]thieno[2,3-d]pyrimidin-4-amine from Example 29A (46 mg, 0.11 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (25 mg, 0.15 mmol) to yield 19 mg (33%).

1. customto yield 19 mg (33%)