2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525852, compound

HRID 385862Notes

Reaction equation

HRID 385862 reaction equation
Br[C:2]1[N:7]=[C:6]([CH2:8][CH2:9][O:10][CH2:11][C:12]([CH3:15])([OH:14])[CH3:13])[CH:5]=[CH:4][CH:3]=1.[NH2:16][C:17]1[S:18][C:19]([C:25]2[C:30]([F:31])=[CH:29][C:28]([C:32]([OH:35])([CH3:34])[CH3:33])=[CH:27][C:26]=2[F:36])=[CH:20][C:21]=1[C:22]([NH2:24])=[O:23]>>[F:36][C:26]1[CH:27]=[C:28]([C:32]([OH:35])([CH3:34])[CH3:33])[CH:29]=[C:30]([F:31])[C:25]=1[C:19]1[S:18][C:17]([NH:16][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][CH2:9][O:10][CH2:11][C:12]([OH:14])([CH3:15])[CH3:13])[N:7]=2)=[C:21]([C:22]([NH2:24])=[O:23])[CH:20]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525768HCID 59525768, compound

Product 1

HCID 59525852HCID 59525852, compound

Procedure

The title compound was prepared according to the general procedure in Example 1 using 1-[2-(6-bromopyridin-2-yl)ethoxy]-2-methylpropan-2-ol (53 mg, 0.19 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (60 mg, 0.19 mmol) as the starting materials.

Sources & evidence

ORD record
ord-8e5b605c78554c2aa979bda1e1846861
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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