2-Bromo-6-(bromomethyl)pyridine → 2-{2-[(6-Bromopyridin-2-yl)methyoxy]ethyl}-2-azaspiro[3.3]heptane

HRID 385869Notes

Reaction equation

HRID 385869 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8]Br)[N:3]=1.[CH2:10]1[C:13]2([CH2:16][CH2:15][CH2:14]2)[CH2:12][N:11]1[CH2:17][CH2:18][OH:19]>>[Br:1][C:2]1[N:3]=[C:4]([CH2:8][O:19][CH2:18][CH2:17][N:11]2[CH2:12][C:13]3([CH2:16][CH2:15][CH2:14]3)[CH2:10]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 129547962-Bromo-6-(bromomethyl)pyridineHCID 450878752-(2-Azaspiro[3.3]heptan-2-yl)ethanol

Product 1

HCID 595262672-{2-[(6-Bromopyridin-2-yl)methyoxy]ethyl}-2-azaspiro[3.3]heptane

Procedure

The title compound was prepared according to Example 251, Step 1 using 2-bromo-6-(bromomethyl)pyridine (Example 190, Step 1) (200 mg, 0.80 mmol) and 2-(2-azaspiro[3.3]hept-2-yl)ethanol (112 mg, 0.80 mmol) as the starting materials.

Sources & evidence

ORD record
ord-e272ac40106e45f18ccecd8f8c636756
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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