HRID385870

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(O)c1ccc(-c2cc(C(N)=O)c(Nc3cccc(C=O)n3)s2)c(F)c1

HCID59526158

未命名化合物

HCID59526267

未命名化合物

PRODUCTS

生成物

结构：CC(C)(O)c1ccc(-c2cc(C(N)=O)c(Nc3cccc(COCCN4CC5(CCC5)C4)n3)s2)c(F)c1

HCID59526136

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to Example 251, Step 2 using 5-(2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl)-2-((6-formyl-2-pyridinyl)amino)-3-thiophenecarboxamide (200 mg, 0.68 mmol) and 2-{2-[(6-bromopyridin-2-yl)methyoxy]ethyl}-2-azaspiro[3.3]heptane (211 mg, 0.68 mmol) as the starting materials.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c3a2828d64244581a0c6f4a99f3b963b
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367706B2
来源说明: uspto-grants-2013_02

反应 SMILES

[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:11])([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[C:12]1[S:16][C:15]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH:24]=[O:25])[N:19]=2)=[C:14]([C:26]([NH2:28])=[O:27])[CH:13]=1.BrC1N=C(CO[CH2:38][CH2:39][N:40]2[CH2:43][C:42]3([CH2:46][CH2:45][CH2:44]3)[CH2:41]2)C=CC=1>>[CH2:41]1[C:42]2([CH2:46][CH2:45][CH2:44]2)[CH2:43][N:40]1[CH2:39][CH2:38][O:25][CH2:24][C:20]1[N:19]=[C:18]([NH:17][C:15]2[S:16][C:12]([C:3]3[CH:4]=[CH:5][C:6]([C:8]([OH:11])([CH3:9])[CH3:10])=[CH:7][C:2]=3[F:1])=[CH:13][C:14]=2[C:26]([NH2:28])=[O:27])[CH:23]=[CH:22][CH:21]=1