2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 178458227, compound

HRID 385878Notes

Reaction equation

HRID 385878 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:22]1[N:27]=[C:26]([C:28]([NH:30][C@H:31]2[CH2:36][CH2:35][C@H:34]([OH:37])[CH2:33][CH2:32]2)=[O:29])[CH:25]=[CH:24][CH:23]=1>>[NH2:9][C:7]([C:6]1[CH:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:17])[CH3:18])=[CH:12][C:11]=2[F:20])[S:3][C:2]=1[NH:1][C:22]1[N:27]=[C:26]([C:28]([NH:30][C@H:31]2[CH2:36][CH2:35][C@H:34]([OH:37])[CH2:33][CH2:32]2)=[O:29])[CH:25]=[CH:24][CH:23]=1)=[O:8]

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 178523806HCID 178523806, compound

Product 1

HCID 178458227HCID 178458227, compound

Procedure

The title compound was prepared as described in Example 1 with 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.11 g, 0.39 mmol) and 6-bromo-N-(trans-4-hydroxycyclohexyl)pyridine-2-carboxamide (0.11 g, 0.38 mmol) as the starting materials.

Sources & evidence

ORD record
ord-192ff8a6bc7b42db8d2a992e34aded65
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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