2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525920, compound

HRID 385886Notes

Reaction equation

HRID 385886 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]([N:10]2[CH2:15][CH2:14][O:13][C@H:12]([CH3:16])[CH2:11]2)=[O:9])[CH:5]=[CH:4][CH:3]=1.[NH2:17][C:18]1[S:19][C:20]([C:26]2[CH:31]=[CH:30][C:29]([C:32]([OH:35])([CH3:34])[CH3:33])=[CH:28][C:27]=2[F:36])=[CH:21][C:22]=1[C:23]([NH2:25])=[O:24]>>[F:36][C:27]1[CH:28]=[C:29]([C:32]([OH:35])([CH3:33])[CH3:34])[CH:30]=[CH:31][C:26]=1[C:20]1[S:19][C:18]([NH:17][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([C:8]([N:10]3[CH2:15][CH2:14][O:13][C@H:12]([CH3:16])[CH2:11]3)=[O:9])[N:7]=2)=[C:22]([C:23]([NH2:25])=[O:24])[CH:21]=1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526327(2R)-4-[(6-Bromopyridin-2-yl)carbonyl]-2-methylmorpholine

Product 1

HCID 59525920HCID 59525920, compound

Procedure

The title compound was prepared as described Example 1 using (2R)-4-[(6-bromopyridin-2-yl)carbonyl]-2-methylmorpholine (133 mg, 0.47 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (137 mg, 0.47 mmol) as starting materials

Sources & evidence

ORD record
ord-805a83ce9e3e49abb3be0cbae8b0970b
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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