HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 2-{[6-(1-Cyano-3-hydroxypropyl)pyridin-2-yl]amino}-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 58216638 | — |
| Reactant | 2-(6-Bromopyridin-2-yl)-4-hydroxybutanenitrile | HCID 59525574 | — |
| Product | 2-{[6-(1-Cyano-3-hydroxypropyl)pyridin-2-yl]amino}-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525763 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Example 1 using 2-(6-bromopyridin-2-yl)-4-hydroxybutanenitrile (97 mg, 0.40 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (118 mg, 0.40 mmol) as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-fdbb22ce9a8149009d4d408a8fddbe0a |
| Source note | uspto-grants-2013_02 |