2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-{2-[(1-methyl-1H-pyrazol-4-yl)amino]-2-oxoethyl}pyridin-2-yl)amino]thiophene-3-carboxamide

HRID 385898Notes

Reaction equation

HRID 385898 reaction equation
Br[C:2]1[N:7]=[C:6]([CH2:8][C:9]([NH:11][C:12]2[CH:13]=[N:14][N:15]([CH3:17])[CH:16]=2)=[O:10])[CH:5]=[CH:4][CH:3]=1.[NH2:18][C:19]1[S:20][C:21]([C:27]2[C:32]([F:33])=[CH:31][C:30]([C:34]([OH:37])([CH3:36])[CH3:35])=[CH:29][C:28]=2[F:38])=[CH:22][C:23]=1[C:24]([NH2:26])=[O:25]>>[F:38][C:28]1[CH:29]=[C:30]([C:34]([OH:37])([CH3:36])[CH3:35])[CH:31]=[C:32]([F:33])[C:27]=1[C:21]1[S:20][C:19]([NH:18][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][C:9]([NH:11][C:12]3[CH:13]=[N:14][N:15]([CH3:17])[CH:16]=3)=[O:10])[N:7]=2)=[C:23]([C:24]([NH2:26])=[O:25])[CH:22]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526207HCID 59526207, compound

Product 1

HCID 595258355-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-{2-[(1-methyl-1H-pyrazol-4-yl)amino]-2-oxoethyl}pyridin-2-yl)amino]thiophene-3-carboxamide

Procedure

The title compound was prepared according to the procedure described in Example 1 using 2-(6-bromopyridin-2-yl)-N-(1-methyl-1-H-pyrazol-4-yl)acetamide (217 mg, 0.74 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (230 mg, 0.74 mmol) as starting materials.

Sources & evidence

ORD record
ord-b2f937a3bf8043868d7be696592ac646
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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