Morpholine → HCID 59526240, compound

Participants

Reaction Steps

Methyl bromo(6-bromopyridin-2-yl)acetate (1.00 g, 3.24 mmol) was taken up in DMF (10 mL) and morpholine (367 μL, 4.21 mmol) and DIEA (848 μL, 4.86 mmol) were added. After maintaining the reaction at room temperature overnight, the reaction was diluted with water and extracted with EtOAc (2×). The combined organic layers were washed with brine, dried over MgSO4, filtered, and evaporated. Silica gel chromatography (0-100% EtOAc/hexanes) afforded the title compound as a yellow oil.

Provenance & Evidence