1,2-Dichloroethane → HCID 59526361, compound

Participants

Reaction Steps

Potassium (6-bromopyridin-2-yl)(morpholin-4-yl)acetate (533 mg, 1.57 mmol), HOBT (361 mg, 2.36 mmol), EDC (452 mg, 2.36 mmol), and methylamine hydrochloride (318 mg, 4.71 mmol) were taken up in DMF (5.0 mL) and DIEA (0.41 mL, 2.36 mmol) was added. The reaction was maintained at room temperature overnight, then diluted with water, and extracted with 5:1 CH2Cl2:MeOH (2×). The combined organic layers were dried over MgSO4, filtered, and evaporated. Silica gel chromatography (0-10% MeOH/CH2Cl2) yielded the title compound as a colorless solid.

Provenance & Evidence