2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59526360, compound

HRID 385903Notes

Reaction equation

HRID 385903 reaction equation
Br[C:2]1[N:7]=[C:6]([CH:8]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:9]([NH:11][CH3:12])=[O:10])[CH:5]=[CH:4][CH:3]=1.[NH2:19][C:20]1[S:21][C:22]([C:28]2[C:33]([F:34])=[CH:32][C:31]([C:35]([OH:38])([CH3:37])[CH3:36])=[CH:30][C:29]=2[F:39])=[CH:23][C:24]=1[C:25]([NH2:27])=[O:26]>>[F:39][C:29]1[CH:30]=[C:31]([C:35]([OH:38])([CH3:37])[CH3:36])[CH:32]=[C:33]([F:34])[C:28]=1[C:22]1[S:21][C:20]([NH:19][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH:8]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[C:9]([NH:11][CH3:12])=[O:10])[N:7]=2)=[C:24]([C:25]([NH2:27])=[O:26])[CH:23]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526361HCID 59526361, compound

Product 1

HCID 59526360HCID 59526360, compound

Procedure

The title compound was synthesized from 2-(6-bromopyridin-2-yl)-N-methyl-2-morpholin-4-ylacetamide (120 mg, 0.38 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (125 mg, 0.40 mmol) according to the procedure described in Example 1.

Sources & evidence

ORD record
ord-66bd76c04ff841159706ff0401188cc0
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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