HCID 59525578, compound → HCID 59525933, compound

HRID 385907Notes

Reaction equation

HRID 385907 reaction equation
Br[C:2]1[N:7]=[C:6]([CH:8]([OH:13])[C:9]([NH:11][CH3:12])=[O:10])[CH:5]=[CH:4][CH:3]=1.[NH2:14][C:15]1[S:16][C:17]([C:23]2[C:28]([F:29])=[CH:27][C:26]([C:30]([OH:33])([CH3:32])[CH3:31])=[CH:25][C:24]=2[F:34])=[CH:18][C:19]=1[C:20]([NH2:22])=[O:21]>>[F:34][C:24]1[CH:25]=[C:26]([C:30]([OH:33])([CH3:32])[CH3:31])[CH:27]=[C:28]([F:29])[C:23]=1[C:17]1[S:16][C:15]([NH:14][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH:8]([OH:13])[C:9]([NH:11][CH3:12])=[O:10])[N:7]=2)=[C:19]([C:20]([NH2:22])=[O:21])[CH:18]=1

Participants

3

Reactant 2

HCID 59525578HCID 59525578, compoundHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 59525933HCID 59525933, compound

Procedure

The title compound was prepared according to the procedure described in Example 1 using 2-(6-bromopyridin-2-yl)-2-hydroxy-N-methylacetamide (94 mg, 0.38 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (126 mg, 0.40 mmol) as starting materials.

Sources & evidence

ORD record
ord-e93226210c764e5285aff8c8f771b8f1
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…