2-(6-Bromopyridin-2-yl)-2-methylpropanenitrile → 2-{[6-(1-Cyano-1-methylethyl)pyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HRID 385909Notes

Reaction equation

HRID 385909 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]([CH3:12])([CH3:11])[C:9]#[N:10])[CH:5]=[CH:4][CH:3]=1.[NH2:13][C:14]1[S:15][C:16]([C:22]2[C:27]([F:28])=[CH:26][C:25]([C:29]([OH:32])([CH3:31])[CH3:30])=[CH:24][C:23]=2[F:33])=[CH:17][C:18]=1[C:19]([NH2:21])=[O:20]>>[C:9]([C:8]([C:6]1[N:7]=[C:2]([NH:13][C:14]2[S:15][C:16]([C:22]3[C:23]([F:33])=[CH:24][C:25]([C:29]([OH:32])([CH3:30])[CH3:31])=[CH:26][C:27]=3[F:28])=[CH:17][C:18]=2[C:19]([NH2:21])=[O:20])[CH:3]=[CH:4][CH:5]=1)([CH3:12])[CH3:11])#[N:10]

Participants

3

Reactant 2

HCID 579696582-(6-Bromopyridin-2-yl)-2-methylpropanenitrileHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595259302-{[6-(1-Cyano-1-methylethyl)pyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Example 1 using 2-(6-bromopyridin-2-yl)-2-methylpropanenitrile (108 mg, 0.48 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) as the starting materials.

Sources & evidence

ORD record
ord-0548309dedf242eb8d47a31acd2335ee
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…