2-(6-Bromopyridin-2-yl)-2-methylpropanamide → 2-{[6-(2-Amino-1,1-dimethyl-2-oxoethyl)pyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HRID 385913Notes

Reaction equation

HRID 385913 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]([CH3:13])([CH3:12])[C:9]([NH2:11])=[O:10])[CH:5]=[CH:4][CH:3]=1.[NH2:14][C:15]1[S:16][C:17]([C:23]2[C:28]([F:29])=[CH:27][C:26]([C:30]([OH:33])([CH3:32])[CH3:31])=[CH:25][C:24]=2[F:34])=[CH:18][C:19]=1[C:20]([NH2:22])=[O:21]>>[NH2:11][C:9](=[O:10])[C:8]([C:6]1[N:7]=[C:2]([NH:14][C:15]2[S:16][C:17]([C:23]3[C:24]([F:34])=[CH:25][C:26]([C:30]([OH:33])([CH3:31])[CH3:32])=[CH:27][C:28]=3[F:29])=[CH:18][C:19]=2[C:20]([NH2:22])=[O:21])[CH:3]=[CH:4][CH:5]=1)([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 595255632-(6-Bromopyridin-2-yl)-2-methylpropanamideHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595257812-{[6-(2-Amino-1,1-dimethyl-2-oxoethyl)pyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Procedure

The title compound was prepared according to the procedure described in Example 1 using 2-(6-bromopyridin-2-yl)-2-methylpropanamide (117 mg, 0.48 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) as starting materials.

Sources & evidence

ORD record
ord-fc65b3c6e3f548df815d982a41320bea
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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