2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-{1,1-dimethyl-2-[(1-methyl-1H-pyrazol-4-yl)amino]-2-oxoethyl}pyridin-2-yl)amino]thiophene-3-carboxamide

HRID 385916Notes

Reaction equation

HRID 385916 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]([CH3:19])([CH3:18])[C:9]([NH:11][C:12]2[CH:13]=[N:14][N:15]([CH3:17])[CH:16]=2)=[O:10])[CH:5]=[CH:4][CH:3]=1.[NH2:20][C:21]1[S:22][C:23]([C:29]2[C:34]([F:35])=[CH:33][C:32]([C:36]([OH:39])([CH3:38])[CH3:37])=[CH:31][C:30]=2[F:40])=[CH:24][C:25]=1[C:26]([NH2:28])=[O:27]>>[F:40][C:30]1[CH:31]=[C:32]([C:36]([OH:39])([CH3:38])[CH3:37])[CH:33]=[C:34]([F:35])[C:29]=1[C:23]1[S:22][C:21]([NH:20][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([C:8]([CH3:19])([CH3:18])[C:9]([NH:11][C:12]3[CH:13]=[N:14][N:15]([CH3:17])[CH:16]=3)=[O:10])[N:7]=2)=[C:25]([C:26]([NH2:28])=[O:27])[CH:24]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595262622-(6-Bromopyridin-2-yl)-2-methyl-N-(1-methyl-1-H-pyrazol-4-yl)propanamide

Product 1

HCID 595257235-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-{1,1-dimethyl-2-[(1-methyl-1H-pyrazol-4-yl)amino]-2-oxoethyl}pyridin-2-yl)amino]thiophene-3-carboxamide

Procedure

The title compound was prepared according to the procedure described in Example 1 using 2-(6-bromopyridin-2-yl)-2-methyl-N-(1-methyl-1-H-pyrazol-4-yl)propanamide (47 mg, 0.14 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (45 mg, 0.14 mmol) as starting materials.

Sources & evidence

ORD record
ord-3843e6cb2c9642a8bb5f9d655dc8a782
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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