HRID385916

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(O)c1cc(F)c(-c2cc(C(N)=O)c(N)s2)c(F)c1

HCID59525619

未命名化合物

HCID59526262

未命名化合物

PRODUCTS

生成物

结构：Cn1cc(NC(=O)C(C)(C)c2cccc(Nc3sc(-c4c(F)cc(C(C)(C)O)cc4F)cc3C(N)=O)n2)cn1

HCID59525723

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in Example 1 using 2-(6-bromopyridin-2-yl)-2-methyl-N-(1-methyl-1-H-pyrazol-4-yl)propanamide (47 mg, 0.14 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (45 mg, 0.14 mmol) as starting materials.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3843e6cb2c9642a8bb5f9d655dc8a782
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367706B2
来源说明: uspto-grants-2013_02

反应 SMILES

Br[C:2]1[N:7]=[C:6]([C:8]([CH3:19])([CH3:18])[C:9]([NH:11][C:12]2[CH:13]=[N:14][N:15]([CH3:17])[CH:16]=2)=[O:10])[CH:5]=[CH:4][CH:3]=1.[NH2:20][C:21]1[S:22][C:23]([C:29]2[C:34]([F:35])=[CH:33][C:32]([C:36]([OH:39])([CH3:38])[CH3:37])=[CH:31][C:30]=2[F:40])=[CH:24][C:25]=1[C:26]([NH2:28])=[O:27]>>[F:40][C:30]1[CH:31]=[C:32]([C:36]([OH:39])([CH3:38])[CH3:37])[CH:33]=[C:34]([F:35])[C:29]=1[C:23]1[S:22][C:21]([NH:20][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([C:8]([CH3:19])([CH3:18])[C:9]([NH:11][C:12]3[CH:13]=[N:14][N:15]([CH3:17])[CH:16]=3)=[O:10])[N:7]=2)=[C:25]([C:26]([NH2:28])=[O:27])[CH:24]=1