2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525825, compound

HRID 385918Notes

Reaction equation

HRID 385918 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:22]1[N:27]=[C:26]([CH2:28][S:29]([CH2:32][C:33]([CH3:36])([OH:35])[CH3:34])(=[O:31])=[O:30])[CH:25]=[CH:24][CH:23]=1>>[F:20][C:11]1[CH:12]=[C:13]([C:16]([OH:19])([CH3:17])[CH3:18])[CH:14]=[CH:15][C:10]=1[C:4]1[S:3][C:2]([NH:1][C:22]2[CH:23]=[CH:24][CH:25]=[C:26]([CH2:28][S:29]([CH2:32][C:33]([OH:35])([CH3:34])[CH3:36])(=[O:31])=[O:30])[N:27]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525584HCID 59525584, compound

Product 1

HCID 59525825HCID 59525825, compound

Procedure

The title compound was prepared using the procedure described in Example 1 with 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.097 g, 0.33 mmol) and 1-{[(6-bromopyridin-2-yl)methyl]sulfonyl}-2-methylpropan-2-ol (0.10 g, 0.32 mmol) as starting materials.

Sources & evidence

ORD record
ord-1a76417766be4a1498dc57a0ce2aa0ff
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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