(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → HCID 58116985, compound

HRID 38593Notes

Reaction equation

HRID 38593 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]2[C:11]3[C:18]4[CH2:19][CH2:20][NH:21][CH2:22][C:17]=4[O:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:6]=[CH:7][CH:8]=1)#[CH:2].Cl.[CH3:24][N:25]([CH3:32])[CH2:26]/[CH:27]=[CH:28]/[C:29](O)=[O:30]>>[CH3:24][N:25]([CH3:32])[CH2:26]/[CH:27]=[CH:28]/[C:29]([N:21]1[CH2:20][CH2:19][C:18]2[C:11]3[C:10]([NH:9][C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([C:1]#[CH:2])[CH:4]=4)=[N:15][CH:14]=[N:13][C:12]=3[O:16][C:17]=2[CH2:22]1)=[O:30]

Participants

3

Reactant 2

HCID 45358758(2E)-4-(Dimethylamino)-2-butenoic acid hydrochlorideHCID 58116895N-(3-Ethynylphenyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]furo[2,3-d]pyrimidin-4-amine

Product 1

HCID 58116985HCID 58116985, compound

Procedure

In analogy to Example 89, the title compound was prepared from N-(3-ethynylphenyl)-5,6,7,8-tetrahydropyrido[4′,3′:4,5]furo[2,3-d]pyrimidin-4-amine from Example 43A (100 mg, 0.344 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (80 mg, 0.48 mmol) to yield 66 mg (46%).

Workup

  1. customto yield 66 mg (46%)

Sources & evidence

ORD record
ord-24d12bd671954b968e16af9392f9ba57
Source dataset
uspto-grants-2013_09
Patent number
US08524722B2

Reaction notes

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