HCID 43581417, compound → HCID 59526124, compound

HRID 385935Notes

Reaction equation

HRID 385935 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[N:28]=[CH:27][C:26]([CH2:29][N:30]2[CH2:35][CH2:34][S:33](=[O:37])(=[O:36])[CH2:32][CH2:31]2)=[CH:25][CH:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:24]=[CH:25][C:26]([CH2:29][N:30]3[CH2:31][CH2:32][S:33](=[O:37])(=[O:36])[CH2:34][CH2:35]3)=[CH:27][N:28]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 43581417HCID 43581417, compoundHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 59526124HCID 59526124, compound

Procedure

The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (41 mg, 0.13 mmol) and 4-[(6-chloropyridin-3-yl)methyl]thiomorpholine 1,1-dioxide (34 mg, 0.13 mmol) as starting materials.

Sources & evidence

ORD record
ord-28b53a565e184370a98d7103877555a3
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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