2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → Ethyl{4-[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-3-yl]-1h-1,2,3-triazol-1-yl}acetate

HRID 385941Notes

Reaction equation

HRID 385941 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].[CH2:22]([O:24][C:25](=[O:39])[CH2:26][N:27]1[CH:31]=[C:30]([C:32]2[CH:33]=[N:34][C:35](Cl)=[CH:36][CH:37]=2)[N:29]=[N:28]1)[CH3:23]>>[CH2:22]([O:24][C:25](=[O:39])[CH2:26][N:27]1[CH:31]=[C:30]([C:32]2[CH:33]=[N:34][C:35]([NH:1][C:2]3[S:3][C:4]([C:10]4[C:11]([F:21])=[CH:12][C:13]([C:17]([OH:20])([CH3:18])[CH3:19])=[CH:14][C:15]=4[F:16])=[CH:5][C:6]=3[C:7]([NH2:9])=[O:8])=[CH:36][CH:37]=2)[N:29]=[N:28]1)[CH3:23]

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526155Ethyl[4-(6-chloropyridin-3-yl)-1H-1,2,3-triazol-1-yl]acetate

Product 1

HCID 59525745Ethyl{4-[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-3-yl]-1h-1,2,3-triazol-1-yl}acetate

Procedure

The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) and ethyl[4-(6-chloropyridin-3-yl)-1H-1,2,3-triazol-1-yl]acetate (128 mg, 0.48 mmol) as starting materials.

Sources & evidence

ORD record
ord-5b09e71d84c842cdbbfc92b34a971c32
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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