2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({5-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]pyridin-2-yl}amino)thiophene-3-carboxamide

Participants

Reaction Steps

The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (100 mg, 0.32 mmol) and 2-[4-(6-chloropyridin-3-yl)-1H-1,2,3-triazol-1-yl]ethanol (72 mg, 0.32 mmol) as starting materials.

Provenance & Evidence