Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → Ammonia
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-(Bromomethyl)-6-chloro-2-methylpyridine | HCID 59526174 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ammonia | HCID 222 | — |
| 생성물 | 4-[(6-Chloro-2-methylpyridin-3-yl)methyl]morpholine | HCID 51341953 | — |
반응 단계
3-(Bromomethyl)-6-chloro-2-methylpyridine (500 mg, 2.27 mmol) was taken up in CH2Cl2 (5.0 mL) and morpholine (257 μL, 2.95 mmol) and DIEA (594 μL, 3.40 mmol) were added. After stirring at room temperature overnight, the reaction was diluted with water and extracted with CH2Cl2 (2×). The combined organic layers were dried over MgSO4, filtered, and evaporated. Flash chromatography (0-10% MeOH (w/2 M NH3)/CH2Cl2) provided the title compound as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08367706B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-d3b4e8cd363f4bcba022ccba1d4517a5 |
| 출처 메모 | uspto-grants-2013_02 |