反应详情

Methyl 6-chloro-2-(chloromethyl)pyridine-3-carboxylate (1.5 g, 6.82 mmol) and potassium carbonate (1.13 g, 8.18 mmol) were taken up in DMF (13 mL) and morpholine (0.59 mL, 6.82 mmol) was added. The mixture was allowed to react at room temperature overnight, at which time water was added and the products extracted into EtOAc (2×). The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as an orange oil.

1. additionwas added
2. extractionthe products extracted into EtOAc (2×)
3. washThe combined organic extracts were washed with brine
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo