Water → Methyl 6-chloro-2-(morpholin-4-ylmethyl)pyridine-3-carboxylate

HRID 385952노트

반응식

HRID 385952 반응식
[Cl:1][C:2]1[N:7]=[C:6]([CH2:8]Cl)[C:5]([C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1.O>CN(C=O)C>[Cl:1][C:2]1[N:7]=[C:6]([CH2:8][N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[C:5]([C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8083MorpholineHCID 11430Potassium CarbonateHCID 59525762Methyl 6-chloro-2-(chloromethyl)pyridine-3-carboxylate

생성물 1

HCID 59525630Methyl 6-chloro-2-(morpholin-4-ylmethyl)pyridine-3-carboxylate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Methyl 6-chloro-2-(chloromethyl)pyridine-3-carboxylate (1.5 g, 6.82 mmol) and potassium carbonate (1.13 g, 8.18 mmol) were taken up in DMF (13 mL) and morpholine (0.59 mL, 6.82 mmol) was added. The mixture was allowed to react at room temperature overnight, at which time water was added and the products extracted into EtOAc (2×). The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as an orange oil.

후처리

  1. additionwas added
  2. extractionthe products extracted into EtOAc (2×)
  3. washThe combined organic extracts were washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8b2d3bdb78d5443f98d9381a3fd4719f
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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