1,2-Dichloroethane → HCID 59525654, compound

Participants

Reaction Steps

Sodium 6-chloro-2-(morpholin-4-ylmethyl)pyridine-3-carboxylate (0.3 g, 1.077 mmol), EDC (0.619 g, 3.23 mmol), HOBt (0.495 g, 3.23 mmol), ammonium chloride (0.173 g, 3.23 mmol) and DIPEA (1.128 mL, 6.46 mmol) were stirred in DMF (10 mL) at room temperature overnight. Additional EDC (0.619 g, 3.23 mmol), HOBt (0.495 g, 3.23 mmol), ammonium chloride (0.173 g, 3.23 mmol) and DIPEA (1.128 mL, 6.46 mmol) were then added and stirring continued at room temperature for 24 hours. Saturated aqueous NaHCO3 was added and the products were extracted into EtOAc (2×). The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as a yellow solid.

Provenance & Evidence