2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525815, compound

HRID 385956Notes

Reaction equation

HRID 385956 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[C:5]([C:15]([NH2:17])=[O:16])=[CH:4][CH:3]=1.[NH2:18][C:19]1[S:20][C:21]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([OH:36])([CH3:35])[CH3:34])=[CH:29][C:28]=2[F:37])=[CH:22][C:23]=1[C:24]([NH2:26])=[O:25]>>[NH2:26][C:24]([C:23]1[CH:22]=[C:21]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([OH:36])([CH3:35])[CH3:34])=[CH:29][C:28]=2[F:37])[S:20][C:19]=1[NH:18][C:2]1[CH:3]=[CH:4][C:5]([C:15]([NH2:17])=[O:16])=[C:6]([CH2:8][N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[N:7]=1)=[O:25]

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525654HCID 59525654, compound

Product 1

HCID 59525815HCID 59525815, compound

Procedure

The title compound was prepared according to the general procedure in Example 1 using 6-chloro-2-(morpholin-4-ylmethyl)pyridine-3-carboxamide (87 mg, 0.34 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (100 mg, 0.34 mmol) as the starting materials.

Sources & evidence

ORD record
ord-a518694f62f54d1a9f5b66ee053df04c
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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