Azidomethyl 2,2-dimethylpropanoate → [4-(6-Chloro-2-methylpyridin-3-yl)-1H-1,2,3-triazol-1-yl]methyl pivalate

HRID 385972Notes

Reaction equation

HRID 385972 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([C:9]#[CH:10])=[CH:4][CH:3]=1.[C:11]([O:17][CH2:18][N:19]=[N+:20]=[N-:21])(=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13]>>[C:11]([O:17][CH2:18][N:19]1[CH:10]=[C:9]([C:5]2[C:6]([CH3:8])=[N:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:21]=[N:20]1)(=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 11521126Azidomethyl 2,2-dimethylpropanoateHCID 127097396-Chloro-3-ethynyl-2-methylpyridine

Product 1

HCID 59525806[4-(6-Chloro-2-methylpyridin-3-yl)-1H-1,2,3-triazol-1-yl]methyl pivalate

Procedure

The title compound was prepared as described in Example 413 Step 2 using 6-chloro-3-ethynyl-2-methylpyridine (Example 432, Step 1) (315 mg, 2.08 mmol) and azidomethyl pivalate (327 mg, 2.08 mmol) as starting materials.

Sources & evidence

ORD record
ord-362bd86fa8a34863981cda20562ea1a2
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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