HRID385975

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(O)c1cc(F)c(-c2cc(C(N)=O)c(N)s2)c(F)c1

HCID59525619

未命名化合物

HCID59526255

未命名化合物

PRODUCTS

生成物

结构：Cc1nc(Nc2sc(-c3c(F)cc(C(C)(C)O)cc3F)cc2C(N)=O)ccc1-c1cnnn1CC(C)(C)O

HCID59526291

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (70 mg, 0.22 mmol) and 1-[5-(6-chloro-2-methylpyridin-3-yl)-1H-1,2,3-triazol-1-yl]-2-methylpropan-2-ol (60 mg, 0.22 mmol) as starting materials.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-665b849c95494190b9e93d3223be9c59
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367706B2
来源说明: uspto-grants-2013_02

反应 SMILES

[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[N:28]=[C:27]([CH3:29])[C:26]([C:30]2[N:34]([CH2:35][C:36]([CH3:39])([OH:38])[CH3:37])[N:33]=[N:32][CH:31]=2)=[CH:25][CH:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:24]=[CH:25][C:26]([C:30]3[N:34]([CH2:35][C:36]([OH:38])([CH3:37])[CH3:39])[N:33]=[N:32][CH:31]=3)=[C:27]([CH3:29])[N:28]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1