Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-[(6-Bromopyridin-2-yl)methyl]morpholine-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromo-6-(bromomethyl)pyridine | HCID 12954796 | — |
| 반응물 | Morpholine-3-carboxylic acid amide hydrochloride | HCID 67166308 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-[(6-Bromopyridin-2-yl)methyl]morpholine-3-carboxamide | HCID 59525573 | — |
반응 단계
2-Bromo-6-(bromomethyl)pyridine (Example 190, Step 1) (150 mg, 0.60 mmol), morpholine-3-carboxamide hydrochloride (100 mg, 0.560 mmol) and potassium carbonate (207 mg, 1.50 mmol) were taken up in DMF (3 mL) and the reaction was maintained at room temperature overnight. Water was then added and the mixture was extracted with EtOAc (2×). The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as an orange oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08367706B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-7cac246ef56c4f029533d89df39a7d61 |
| 출처 메모 | uspto-grants-2013_02 |