2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 4-{[6-({3-(Aminocarbonyl)-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}morpholine-3-carboxamide

HRID 385991Notes

Reaction equation

HRID 385991 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:22]1[N:27]=[C:26]([CH2:28][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH:30]2[C:35]([NH2:37])=[O:36])[CH:25]=[CH:24][CH:23]=1>>[NH2:9][C:7]([C:6]1[CH:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:17])[CH3:18])=[CH:12][C:11]=2[F:20])[S:3][C:2]=1[NH:1][C:22]1[N:27]=[C:26]([CH2:28][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH:30]2[C:35]([NH2:37])=[O:36])[CH:25]=[CH:24][CH:23]=1)=[O:8]

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595255734-[(6-Bromopyridin-2-yl)methyl]morpholine-3-carboxamide

Product 1

HCID 595260254-{[6-({3-(Aminocarbonyl)-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}morpholine-3-carboxamide

Procedure

The title compound was prepared as described in Example 1 using 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (80 mg, 0.27 mmol) and 4-[(6-bromopyridin-2-yl)methyl]morpholine-3-carboxamide (82 mg, 0.27 mmol) as starting materials.

Sources & evidence

ORD record
ord-08b0f3d29a1a46f0b2ffbd5936399831
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…