2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525822, compound

HRID 385992Notes

Reaction equation

HRID 385992 reaction equation
Br[C:2]1[N:7]=[C:6]([CH:8]([F:16])[CH2:9][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[CH:4][CH:3]=1.[NH2:17][C:18]1[S:19][C:20]([C:26]2[CH:31]=[CH:30][C:29]([C:32]([OH:35])([CH3:34])[CH3:33])=[CH:28][C:27]=2[F:36])=[CH:21][C:22]=1[C:23]([NH2:25])=[O:24]>>[F:36][C:27]1[CH:28]=[C:29]([C:32]([OH:35])([CH3:33])[CH3:34])[CH:30]=[CH:31][C:26]=1[C:20]1[S:19][C:18]([NH:17][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH:8]([F:16])[CH2:9][N:10]3[CH2:15][CH2:14][O:13][CH2:12][CH2:11]3)[N:7]=2)=[C:22]([C:23]([NH2:25])=[O:24])[CH:21]=1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526176HCID 59526176, compound

Product 1

HCID 59525822HCID 59525822, compound

Procedure

The title compound was prepared according to the general procedure in Example 1 using 4-[2-(6-bromopyridin-2-yl)-2-fluoroethyl]morpholine (80 mg, 0.28 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (81 mg, 0.28 mmol) as the starting materials.

Sources & evidence

ORD record
ord-4aa8b3ebf99a4753b498313092d926d2
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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