2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methyl ethyl)phenyl]-2-{[6-(2-methoxy-1-morpholin-4-ylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 385994Notes

Reaction equation

HRID 385994 reaction equation
Br[C:2]1[N:7]=[C:6]([CH:8]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH2:9][O:10][CH3:11])[CH:5]=[CH:4][CH:3]=1.[NH2:18][C:19]1[S:20][C:21]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([OH:36])([CH3:35])[CH3:34])=[CH:29][C:28]=2[F:37])=[CH:22][C:23]=1[C:24]([NH2:26])=[O:25]>>[F:37][C:28]1[CH:29]=[C:30]([C:33]([OH:36])([CH3:34])[CH3:35])[CH:31]=[CH:32][C:27]=1[C:21]1[S:20][C:19]([NH:18][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH:8]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[CH2:9][O:10][CH3:11])[N:7]=2)=[C:23]([C:24]([NH2:26])=[O:25])[CH:22]=1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595258104-[1-(6-Bromopyridin-2-yl)-2-methoxyethyl]morpholine

Product 1

HCID 595256825-[2-Fluoro-4-(1-hydroxy-1-methyl ethyl)phenyl]-2-{[6-(2-methoxy-1-morpholin-4-ylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Example 1 using 4-[1-(6-bromopyridin-2-yl)-2-methoxyethyl]morpholine (111 mg, 0.37 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (108 mg, 0.37 mmol) as the starting materials.

Sources & evidence

ORD record
ord-c377e9538ddb4ddf839460e530fe14bc
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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