2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59526133, compound

HRID 386000Notes

Reaction equation

HRID 386000 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([O:34][CH3:35])([O:32][CH3:33])[CH2:30][F:31])[N:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([O:32][CH3:33])([O:34][CH3:35])[CH2:30][F:31])[N:24]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525647HCID 59525647, compound

Product 1

HCID 59526133HCID 59526133, compound

Procedure

The title compound was prepared in the same manner described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (100 mg, 0.32 mmol) and 2-bromo-6-(2-fluoro-1,1-dimethoxyethyl)pyridine (85 mg, 0.32 mmol) as starting materials.

Sources & evidence

ORD record
ord-fc7e4854aadf41dfac9f9379c6249ad0
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…