Hydrochloric Acid → HCID 86646277, compound

Participants

Reaction Steps

5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-fluoro-1,1-dimethoxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide (61 mg, 0.12 mmol) was taken up in acetonitrile (1.2 ml) at room temperature. Hydrochloric acid (0.31 ml, 0.62 mmol) was added in one portion, and the reaction mixture was stirred overnight at room temperature. The reaction was quenched with saturated aqueous sodium bicarbonate and extracted three times with ethyl acetate. All organic layers were combined, dried over anhydrous magnesium sulfate, filtered, and concentrated to afford the title compound. Calc'd for C21H19F3N3O3S [M+H]+: 450. Found: 450.

Provenance & Evidence