Sodium borohydride → HCID 59525813, compound

Participants

Reaction Steps

In a dry flask, 5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(fluoroacetyl)pyridin-2-yl]amino}thiophene-3-carboxamide (33.6 mg, 0.08 mmol) was taken up in methanol (0.75 ml) at room temperature. Sodium borohydride (6 mg, 0.15 mmol) was added in small portions and the reaction mixture was stirred at room temperature overnight. The reaction was quenched with aqueous sodium bicarbonate and extracted three times with ethyl acetate. All organic layers were combined, dried over anhydrous magnesium sulfate, filtered, and concentrated. The crude residue was purified by silica gel chromatography (0-100% ethyl acetate/hexanes) to afford the title compound.

Provenance & Evidence