HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(6-Chloropyridin-3-yl)-2,2,2-trifluoroethan-1-ol → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[5-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(6-Chloropyridin-3-yl)-2,2,2-trifluoroethan-1-ol | HCID 19971581 | — |
| Reactant | 2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 58216638 | — |
| Product | 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[5-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide | HCID 59526159 | — |
Reaction Steps
The title compound was prepared as described in Example 1 using 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.51 mmol) and 1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethanol (108 mg, 0.51 mmol) as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-ebabc08d526541359645418a98f2ef13 |
| Source note | uspto-grants-2013_02 |