HCID 11458395, compound → HCID 59526107, compound

HRID 386010Notes

Reaction equation

HRID 386010 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].[Cl:21][C:22]1[C:27]([C:28]([OH:31])([CH3:30])[CH3:29])=[CH:26][CH:25]=[C:24](Cl)[N:23]=1>>[Cl:21][C:22]1[N:23]=[C:24]([NH:1][C:2]2[S:3][C:4]([C:10]3[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:17])[CH3:18])=[CH:12][C:11]=3[F:20])=[CH:5][C:6]=2[C:7]([NH2:9])=[O:8])[CH:25]=[CH:26][C:27]=1[C:28]([OH:31])([CH3:29])[CH3:30]

Participants

3

Reactant 2

HCID 11458395HCID 11458395, compoundHCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 59526107HCID 59526107, compound

Procedure

The title compound was prepared as described in Example 1 using 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (300 mg, 1.02 mmol) and 2-(2,6-dichloropyridin-3-yl)propan-2-ol (210 mg, 1.02 mmol) as starting materials.

Sources & evidence

ORD record
ord-fec9ef84b0974635a0e05ff86d043939
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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